Cognitive SATP for Airborne Radar Based on Slow-Time Coding

Space-time adaptive processing (STAP) techniques have been motivated as a key enabling technology for advanced airborne radar applications. In this paper, the notion of cognitive radar is extended to STAP technique, and cognitive STAP is discussed. The principle for improving signal-to-clutter ratio (SCNR) based on slow-time coding is given, and the corresponding optimization algorithm based on cyclic and power-like algorithms is presented. Numerical examples show the effectiveness of the proposed method

Cromolyn prevents cerebral vasospasm and dementia by targeting WDR43

BackgroundCerebral vasospasm (CV) can cause inflammation and damage to neuronal cells in the elderly, leading to dementia.PurposeThis study aimed to investigate the genetic mechanisms underlying dementia caused by CV in the elderly, identify preventive and therapeutic drugs, and evaluate their efficacy in treating neurodegenerative diseases.MethodsGenes associated with subarachnoid hemorrhage and CV were acquired and screened for differentially expressed miRNAs (DEmiRNAs) associated with aneurysm rupture. A regulatory network of DEmiRNAs and mRNAs was constructed, and virtual screening was performed to evaluate possible binding patterns between Food and Drug Administration (FDA)-approved drugs and core proteins. Molecular dynamics simulations were performed on the optimal docked complexes. Optimally docked drugs were evaluated for efficacy in the treatment of neurodegenerative diseases through cellular experiments.ResultsThe study found upregulated genes (including WDR43 and THBS1) and one downregulated gene associated with aneurysm rupture. Differences in the expression of these genes indicate greater disease risk. DEmiRNAs associated with ruptured aortic aneurysm were identified, of which two could bind to THBS1 and WDR43. Cromolyn and lanoxin formed the best docking complexes with WDR43 and THBS1, respectively. Cellular experiments showed that cromolyn improved BV2 cell viability and enhanced Aβ42 uptake, suggesting its potential as a therapeutic agent for inflammation-related disorders.ConclusionThe findings suggest that WDR43 and THBS1 are potential targets for preventing and treating CV-induced dementia in the elderly. Cromolyn may have therapeutic value in the treatment of Alzheimer’s disease and dementia

Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes

CD73, an ectonucleotidase, participates in the regulation of immune responses by controlling the conversion of extracellular AMP to adenosine. In this study, we investigated whether any type of brain cells, especially neuroglia cells, exhibit altered CD73 expression, localization or activity upon experimental autoimmune uveitis (EAU) induction and whether altered CD73 manipulates the activation of effector T cells that interact with such cell types. First, the amount of cell membrane-exposed CD73 was detected by flow cytometry in various types of brain cells collected from either naïve or EAE mice. Compared to that in astrocytes from naïve control mice, the amount of membrane-bound CD73 was significantly decreased in astrocytes from EAE mice, while no significant differences were detected in other cell types. Thereafter, wild-type and CD73-/- astrocytes were used to study whether CD73 influences the function of inflammatory astrocytes, such as the production of cytokines/chemokines and the activation of effector T cells that interact with astrocytes. The results indicated that the addition of exogenous AMP significantly inhibited cytokine/chemokine production by wild type astrocytes but had no effect on CD73-/- astrocytes and that the effect of AMP was almost completely blocked by the addition of either a CD73 inhibitor (APCP) or an adenosine receptor A1 subtype (ARA1) antagonist (DPCPX). Although the addition of AMP did not affect CD73-/- astrocytes, the addition of adenosine successfully inhibited their cytokine/chemokine production. The antigen-specific interaction of astrocytes with invading CD4 cells caused CD73 downregulation in astrocytes from mice that underwent EAE induction. Collectively, our findings support the conclusion that, upon EAE induction, likely due to an interaction with invading CD4+ cells, astrocytes lose most of their membrane-localized CD73; this inhibits the generation of adenosine in the local microenvironment. As adenosine has anti-inflammatory effects on astrocytes and CNS-infiltrating effector T cells in EAE, the downregulation of CD73 in astrocytes may be considered a pro-inflammatory process for facilitating the pathogenesis of EAE

Spatiotemporal Simulation of Tourist Town Growth Based on the Cellular Automata Model: The Case of Sanpo Town in Hebei Province

Spatiotemporal simulation of tourist town growth is important for research on land use/cover change under the influence of urbanization. Many scholars have shown great interest in the unique pattern of driving urban development with tourism development. Based on the cellular automata (CA) model, we simulated and predicted the spatiotemporal growth of Sanpo town in Hebei Province, using the tourism urbanization growth model. Results showed that (1) average annual growth rate of the entire region was 1.5 Ha2 per year from 2005 to 2010, 4 Ha2 per year from 2010 to 2015, and 2.5 Ha2 per year from 2015 to 2020; (2) urban growth rate increased yearly, with regional differences, and had a high degree of correlation with the Euclidean distance of town center, traffic route, attractions, and other factors; (3) Gougezhuang, an important village center in the west of the town, demonstrated traffic advantages and increased growth rate since 2010; (4) Magezhuang village has the largest population in the region, so economic advantages have driven the development of rural urbanization. It showed that CA had high reliability in simulating the spatiotemporal evolution of tourist town, which assists the study of spatiotemporal growth under urbanization and rational protection of tourism resources

A spectral-spatial feature extraction method with polydirectional CNN for multispectral image compression

Convolutional neural networks (CNN) has been widely used in the research of multispectral image compression, but they still face the challenge of extracting spectral feature effectively while preserving spatial feature with integrity. In this article, a novel spectral-spatial feature extraction method is proposed with polydirectional CNN (SSPC) for multispectral image compression. First, the feature extraction network is divided into three parallel modules. The spectral module is employed to obtain spectral features along the spectral direction independently, and simultaneously, with two spatial modules extracting spatial features along two different spatial directions. Then all the features are fused together, followed by downsampling to reduce the size of the feature maps. To control the tradeoff between the rate loss and the distortion, the rate-distortion optimizer is added to the network. In addition, quantization and entropy encoding are applied in turn, converting the data into bit stream. The decoder is structurally symmetric to the encoder, which is convenient for structuring the framework to recover the image. For comparison, SSPC is tested along with JPEG2000 and three-dimensional (3-D) SPIHT on the multispectral datasets of Landsat-8 and WorldView-3 satellites. Besides, to further validate the effectiveness of polydirectional CNN, SSPC is also compared with a normal CNN-based algorithm. The experimental results show that SSPC outperforms other methods at the same bit rates, which demonstrates the validity of the spectral-spatial feature extraction method with polydirectional CNN

Spectral–Spatial Feature Partitioned Extraction Based on CNN for Multispectral Image Compression

Recently, the rapid development of multispectral imaging technology has received great attention from many fields, which inevitably involves the image transmission and storage problem. To solve this issue, a novel end-to-end multispectral image compression method based on spectral–spatial feature partitioned extraction is proposed. The whole multispectral image compression framework is based on a convolutional neural network (CNN), whose innovation lies in the feature extraction module that is divided into two parallel parts, one is for spectral and the other is for spatial. Firstly, the spectral feature extraction module is used to extract spectral features independently, and the spatial feature extraction module is operated to obtain the separated spatial features. After feature extraction, the spectral and spatial features are fused element-by-element, followed by downsampling, which can reduce the size of the feature maps. Then, the data are converted to bit-stream through quantization and lossless entropy encoding. To make the data more compact, a rate-distortion optimizer is added to the network. The decoder is a relatively inverse process of the encoder. For comparison, the proposed method is tested along with JPEG2000, 3D-SPIHT and ResConv, another CNN-based algorithm on datasets from Landsat-8 and WorldView-3 satellites. The result shows the proposed algorithm outperforms other methods at the same bit rate

Sparse Unmixing of Hyperspectral Data by Exploiting Joint-Sparsity and Rank-Deficiency

In this work, we exploit two assumed properties of the abundances of the observed signatures (endmembers) in order to reconstruct the abundances from hyperspectral data. Joint-sparsity is the first property of the abundances, which assumes the adjacent pixels can be expressed as different linear combinations of same materials. The second property is rank-deficiency where the number of endmembers participating in hyperspectral data is very small compared with the dimensionality of spectral library, which means that the abundances matrix of the endmembers is a low-rank matrix. These assumptions lead to an optimization problem for the sparse unmixing model that requires minimizing a combined l2,p-norm and nuclear norm. We propose a variable splitting and augmented Lagrangian algorithm to solve the optimization problem. Experimental evaluation carried out on synthetic and real hyperspectral data shows that the proposed method outperforms the state-of-the-art algorithms with a better spectral unmixing accuracy

A Study of Library Window Seat Consumption and Learning Efficiency Based on the ABC Attitude Model and the Proposal of a Library Service Optimization Strategy

The aim of this study is to determine the relationship between occupants’ emotional attitude, decision behavior, and environmental cognition toward window seats and learning efficiency and the mechanism of this relationship in public spaces (represented by academic libraries). Surveys were delivered to the academic library of Shanghai Jiao Tong University. A total of 280 valid face-to-face interview questionnaires was collected and analyzed for correlation and validation of theoretical models. The results show that learning experience, as a mediator of learning efficiency, has a significant impact on the model of occupants’ attitude toward window seat consumption. The impact mechanism was determined, and it indicated that in order to improve the learning efficiency of occupants, indoor re-planning should be carried out to improve the seat satisfaction and occupancy rate. This study introduces the concepts of service design and architectural consumption and constructs an occupant emotional consumption context with the window seat as the consumption product. In addition, it also has guiding value for seat reallocation in public buildings in the COVID-19 era. This theoretical framework provides a direction for the simulation of future construction consumption behavior

A Study of Library Window Seat Consumption and Learning Efficiency Based on the ABC Attitude Model and the Proposal of a Library Service Optimization Strategy

The aim of this study is to determine the relationship between occupants’ emotional attitude, decision behavior, and environmental cognition toward window seats and learning efficiency and the mechanism of this relationship in public spaces (represented by academic libraries). Surveys were delivered to the academic library of Shanghai Jiao Tong University. A total of 280 valid face-to-face interview questionnaires was collected and analyzed for correlation and validation of theoretical models. The results show that learning experience, as a mediator of learning efficiency, has a significant impact on the model of occupants’ attitude toward window seat consumption. The impact mechanism was determined, and it indicated that in order to improve the learning efficiency of occupants, indoor re-planning should be carried out to improve the seat satisfaction and occupancy rate. This study introduces the concepts of service design and architectural consumption and constructs an occupant emotional consumption context with the window seat as the consumption product. In addition, it also has guiding value for seat reallocation in public buildings in the COVID-19 era. This theoretical framework provides a direction for the simulation of future construction consumption behavior

Image_2_Cromolyn prevents cerebral vasospasm and dementia by targeting WDR43.TIF

BackgroundCerebral vasospasm (CV) can cause inflammation and damage to neuronal cells in the elderly, leading to dementia.PurposeThis study aimed to investigate the genetic mechanisms underlying dementia caused by CV in the elderly, identify preventive and therapeutic drugs, and evaluate their efficacy in treating neurodegenerative diseases.MethodsGenes associated with subarachnoid hemorrhage and CV were acquired and screened for differentially expressed miRNAs (DEmiRNAs) associated with aneurysm rupture. A regulatory network of DEmiRNAs and mRNAs was constructed, and virtual screening was performed to evaluate possible binding patterns between Food and Drug Administration (FDA)-approved drugs and core proteins. Molecular dynamics simulations were performed on the optimal docked complexes. Optimally docked drugs were evaluated for efficacy in the treatment of neurodegenerative diseases through cellular experiments.ResultsThe study found upregulated genes (including WDR43 and THBS1) and one downregulated gene associated with aneurysm rupture. Differences in the expression of these genes indicate greater disease risk. DEmiRNAs associated with ruptured aortic aneurysm were identified, of which two could bind to THBS1 and WDR43. Cromolyn and lanoxin formed the best docking complexes with WDR43 and THBS1, respectively. Cellular experiments showed that cromolyn improved BV2 cell viability and enhanced Aβ42 uptake, suggesting its potential as a therapeutic agent for inflammation-related disorders.ConclusionThe findings suggest that WDR43 and THBS1 are potential targets for preventing and treating CV-induced dementia in the elderly. Cromolyn may have therapeutic value in the treatment of Alzheimer’s disease and dementia.</p